Acetone → HCID 58691330, compound

HRID 1594487Notes

Reaction equation

[C:1]([NH:4][C:5]1[S:6][C:7]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][C:15]3[N:20]=[CH:19][N:18]=[C:17]([C:21]4[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=4[NH:31][C:32](C4CCCN4)=[O:33])[CH:16]=3)[C:8]=2[N:9]=1)(=[O:3])[CH3:2].[CH3:39][C:40]([CH3:42])=O>>[C:1]([NH:4][C:5]1[S:6][C:7]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][C:15]3[N:20]=[CH:19][N:18]=[C:17]([C:21]4[CH:26]=[CH:25][C:24]([C:27]([F:28])([F:29])[F:30])=[CH:23][C:22]=4[NH:31][C:32]([CH:40]4[CH2:42][CH2:5][N:9]([CH:8]([CH3:10])[CH3:7])[CH2:39]4)=[O:33])[CH:16]=3)[C:8]=2[N:9]=1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 180Acetone

HCID 75050654HCID 75050654, compound

Product 1

HCID 58691330HCID 58691330, compound

Procedure

The title compound was prepared by reacting N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)pyrrolidine-2-carboxamide [Example 62(b)] with acetone under the conditions of Example 3(d). MS (ESI, pos. ion.) m/z: 585 (M+1).

Sources & evidence

ORD record: ord-6a27f1b706244d1f898bdb69dfd025c8
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07301022B2

Reaction notes

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