HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanecarboxaldehyde → (2S,5R)-N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-(cyclopropylmethyl)-5-phenylpyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanecarboxaldehyde | HCID 123114 | — |
| Reactant | (2S,5R)-N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-5-phenylpyrrolidine-2-carboxamide | HCID 58691316 | — |
| Product | (2S,5R)-N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-(cyclopropylmethyl)-5-phenylpyrrolidine-2-carboxamide | HCID 58691424 | — |
Reaction Steps
(2S,5R)-N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-5-phenylpyrrolidine-2-carboxamide, Example 60, (62 mg, 0.1 mmol) was reacted with cyclopropanecarboxaldehyde (0.009 mL, 0.12 mmol, Aldrich) under the conditions of Example 3(d) to give the title compound as a white solid. MS (ESI, pos. ion.) m/z: 673 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07301022B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-dfa588bf025547caa05f21c1b21a13e4 |
| Source note | uspto-grants-2007_11 |