Acetone → (2S,5R)-N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-isopropyl-5-phenylpyrrolidine-2-carboxamide

Participants

Reaction Steps

(2S,5R)-N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-5-phenylpyrrolidine-2-carboxamide, Example 60, (62 mg, 0.1 mmol) was reacted with acetone (0.009 mL, 0.12 mmol) under the conditions of Example 3(d) to give the title compound as a white solid (51 mg, 78%). MS (ESI, pos. ion.) m/z: 661 (M+1).

Provenance & Evidence