HuagongsheHuagongshe Chemistry Print Report · For research reference only
9-(Phenylmethyl)-9H-purin-6-amine → 9-Benzyl-8-bromoadenine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 9-(Phenylmethyl)-9H-purin-6-amine | HCID 20262 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 9-Benzyl-8-bromoadenine | HCID 9904551 | — |
Reaction Steps
A solution of N9-benzyladenine (1 mmol) in acetic acid buffer (pH=4) was treated with bromine (1 mmol) at room temperature for 12 h. The reaction was quenched with 10% sodium sulfite solution and extracted with dichloromethane. The combined extracts were dried (Na2SO4) and evaporated to dryness. Chromatography afforded N9-benzyl-8-bromoadenine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06284748B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-e7a6874e73a1461bbd542e21ed002c60 |
| Source note | uspto-grants-2001_09 |