HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → N9-benzyl-8-(2-phosphonoethylamino)adenine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 9-Benzyl-8-bromoadenine | HCID 9904551 | — |
| Reactant | HCID 23421211 | HCID 23421211 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | N9-benzyl-8-(2-phosphonoethylamino)adenine | HCID 42637648 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
A mixture of N9-benzyl-8-bromoadenine (1 mmol), aminoethylphosphonate (2 mmol), and sodium hydroxide (2 mmol) in ethanol-water in a sealed tube was warmed at 110° C. under nitrogen. After 24 h the cooled reaction mixture was purified through preparative HPLC to give N9-benzyl-8-(2-phosphonoethylamino)adenine (3.1). Exact mass calculated for C14H17N6O3P+H+: 349.1178. Found: 349.1180.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06284748B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-d8b92ad73ba7448398e559909f0780e2 |
| Source note | uspto-grants-2001_09 |