HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-Diethylphosphonothiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Diethyl chlorophosphate | HCID 13139 | — |
| Reactant | HCID 178418439 | HCID 178418439 | — |
| Product | 2-Diethylphosphonothiophene | HCID 4254391 | — |
Reaction Steps
A solution of 2-thienyllithium in THF (1 mmol) was added to a solution of diethyl chlorophosphate (1 mmol) at −78° C. under nitrogen. After 2 h the reaction was warmed to room temperature and quenched with brine. Extraction and chromatography afforded 2-diethylphosphonothiophene as a yellow oil. TLC: Rf=0.37, 50% EtOAc—hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06284748B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-3cc1e490b65241a19d29b3eec3b56146 |
| Source note | uspto-grants-2001_09 |