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5-Ethynyl-4-methyl-3-nitro-2-pyridone → 3-Amino-5-ethyl-4-methyl-2-pyridone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Ethynyl-4-methyl-3-nitro-2-pyridone | HCID 21706483 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol ethylacetate | HCID 21584252 | — |
| 生成物 | 3-Amino-5-ethyl-4-methyl-2-pyridone | HCID 21706539 | — |
反応手順
A mixture of 5-ethynyl-4-methyl-3-nitro-2-pyridone (0.18 g, 0.6 mmol) and 10% Pd/C (0.02 g) in ethanol/ethyl acetate (50 mL, 1/1) was hydrogenated at 35 psi in a Parr apparatus overnight. The catalyst was removed by filtration, and the solvents were evaporated to give 3-amino-5-ethyl-4-methyl-2-pyridone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06284768B1 |
| 出典データセット | uspto-grants-2001_09 |
| ORD ID | ord-abeedba5a3a94e50a056c83d2c0ea3c4 |
| 出典メモ | uspto-grants-2001_09 |