4-Fluorobenzenesulfonyl chloride → 2-(4-Fluorophenyl)-1-[(4-fluorophenyl)sulfonyl]pyrrolidine

HRID 1594704Notes

Reaction equation

HRID 1594704 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[F:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:9]2[CH2:10][CH2:11][CH2:12][CH:8]2[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)(=[O:22])=[O:21])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 38655602-(4-Fluorophenyl)pyrrolidine

Product 1

HCID 217067732-(4-Fluorophenyl)-1-[(4-fluorophenyl)sulfonyl]pyrrolidine

Procedure

The title compound, light brown solid, m.p. 121° C. and MS: m/e=324.2 (M+H+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and 4-fluoro-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-4b558d801f4f4003b9af5954ceb9ca7c
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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