3-Methylbenzenesulphonyl chloride → (RS)-2-(4-Fluoro-phenyl)-1-(toluene-3-sulfonyl)-pyrrolidine

HRID 1594705Notes

Reaction equation

HRID 1594705 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[C:13]1([CH3:23])[CH:18]=[CH:17][CH:16]=[C:15]([S:19](Cl)(=[O:21])=[O:20])[CH:14]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2[S:19]([C:15]2[CH:14]=[C:13]([CH3:23])[CH:18]=[CH:17][CH:16]=2)(=[O:21])=[O:20])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27345953-Methylbenzenesulphonyl chlorideHCID 38655602-(4-Fluorophenyl)pyrrolidine

Product 1

HCID 21706742(RS)-2-(4-Fluoro-phenyl)-1-(toluene-3-sulfonyl)-pyrrolidine

Procedure

The title compound, light brown solid, m.p. 102° C. and MS: m/e=319 (M+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and toluene-3-sulfonyl chloride.

Sources & evidence

ORD record
ord-e7e3ff42190a4d9093fda8fa281103aa
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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