p-Bromobenzenesulfonyl chloride → HCID 21706730, compound

HRID 1594713Notes

Reaction equation

HRID 1594713 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:9]2[CH2:10][CH2:11][CH2:12][CH:8]2[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)(=[O:22])=[O:21])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 38655602-(4-Fluorophenyl)pyrrolidine

Product 1

HCID 21706730HCID 21706730, compound

Procedure

The title compound, off-white solid, m.p. 131° C. and MS: m/e=383 (M+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and 4-bromo-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-2074009b8efa4dc1aeadbd3a261a8de7
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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