4-Chlorobenzenesulfonyl chloride → HCID 21706767, compound

HRID 1594725Notes

Reaction equation

HRID 1594725 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][CH2:12][CH2:11][NH:10]2)[CH:5]=[CH:6][C:7]=1[F:8].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([N:10]2[CH2:11][CH2:12][CH2:13][CH:9]2[C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=2)(=[O:23])=[O:22])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 217067772-(3,4-Difluorophenyl)pyrrolidine

Product 1

HCID 21706767HCID 21706767, compound

Procedure

The title compound, white solid, m.p. 121° C. and MS: m/e=358.1 (M+H+) was prepared in accordance with the general method of example 1e from (RS)-2-(3,4-difluoro-phenyl)-pyrrolidine and 4-chloro-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-515a8affdd9844699f19d832bd165be3
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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