4-Chlorobenzenesulfonyl chloride → HCID 21706764, compound

HRID 1594726Notes

Reaction equation

HRID 1594726 reaction equation
[CH3:1][N:2]([CH3:15])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:13][CH2:12][CH2:11][NH:10]2)=[CH:5][C:4]=1[F:14].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([N:10]2[CH2:11][CH2:12][CH2:13][CH:9]2[C:6]2[CH:7]=[CH:8][C:3]([N:2]([CH3:15])[CH3:1])=[C:4]([F:14])[CH:5]=2)(=[O:25])=[O:24])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 217067562-Fluoro-N,N-dimethyl-4-(2-pyrrolidinyl)benzenamine

Product 1

HCID 21706764HCID 21706764, compound

Procedure

The title compound, white solid, m.p. 99° C. and MS: m/e=383.2 (M+H+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-dimethylamino-3-fluoro-phenyl)-pyrrolidine and 4-chloro -benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-1bf93ce4d24b4160aa6af868b15c5f05
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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