4-Chlorobenzenesulfonyl chloride → HCID 21706769, compound

HRID 1594728Notes

Reaction equation

HRID 1594728 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][CH2:12][CH2:11][NH:10]2)[CH:5]=[CH:6][C:7]=1[F:8].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([N:10]2[CH2:11][CH2:12][CH2:13][CH:9]2[C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Cl:1])[CH:3]=2)(=[O:23])=[O:22])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 21706772HCID 21706772, compound

Product 1

HCID 21706769HCID 21706769, compound

Procedure

The title compound, off-white solid, m.p. 119° C. and MS: m/e=374.2 (M+H+) was prepared in accordance with the general method of example 1e from (RS)-2-(3-chloro-4-fluoro-phenyl)-pyrrolidine and 4-chloro-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-65783dc7911e40d0b9e4f1adb2f6f08a
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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