4-Fluorobenzenesulfonyl chloride → HCID 21706713, compound

HRID 1594729Notes

Reaction equation

HRID 1594729 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][CH2:12][CH2:11][NH:10]2)[CH:5]=[CH:6][C:7]=1[F:8].[F:14][C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][CH2:12][CH2:11][N:10]2[S:21]([C:18]2[CH:19]=[CH:20][C:15]([F:14])=[CH:16][CH:17]=2)(=[O:23])=[O:22])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 21706772HCID 21706772, compound

Product 1

HCID 21706713HCID 21706713, compound

Procedure

The title compound, white solid, m.p. 116° C. and MS: m/e=358.1 (M+) was prepared in accordance with the general method of example 1e from (RS)-2-(3-chloro-4-fluoro-phenyl)-pyrrolidine and 4-fluoro-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-43fa201872a2486887ee4df6d6573d86
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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