2-Chloro-p-toluenesulfochloride → HCID 21706766, compound

HRID 1594745Notes

Reaction equation

HRID 1594745 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:15]=[C:16]([S:21](Cl)(=[O:23])=[O:22])[CH:17]=[CH:18][C:19]=1[CH3:20]>>[Cl:13][C:14]1[CH:15]=[C:16]([S:21]([N:9]2[CH2:10][CH2:11][CH2:12][CH:8]2[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)(=[O:23])=[O:22])[CH:17]=[CH:18][C:19]=1[CH3:20]

Participants

3

Reactant 2

HCID 2597442-Chloro-p-toluenesulfochlorideHCID 38655602-(4-Fluorophenyl)pyrrolidine

Product 1

HCID 21706766HCID 21706766, compound

Procedure

The title compound, off-white solid, m.p. 134° C. and MS: m/e=353 (M+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and 3-chloro-4-methyl-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-8383a793317c4327b5147b54c99f3029
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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