2-Fluorobenzenesulphonyl chloride → HCID 21706729, compound

HRID 1594746Notes

Reaction equation

HRID 1594746 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20](Cl)(=[O:22])=[O:21]>>[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20]([N:9]1[CH2:10][CH2:11][CH2:12][CH:8]1[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 1377612-Fluorobenzenesulphonyl chlorideHCID 38655602-(4-Fluorophenyl)pyrrolidine

Product 1

HCID 21706729HCID 21706729, compound

Procedure

The title compound, off-white solid, m.p.91° C. and MS: m/e=323 (M+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and 2-fluoro-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-e9f4e1900e2f406db017d4415e741231
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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