2-Naphthalenesulfonyl chloride → HCID 21706739, compound

HRID 1594749Notes

Reaction equation

HRID 1594749 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[S:23](Cl)(=[O:25])=[O:24]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2[S:23]([C:14]2[CH:15]=[CH:16][C:17]3[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:13]=2)(=[O:25])=[O:24])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 38655602-(4-Fluorophenyl)pyrrolidine

Product 1

HCID 21706739HCID 21706739, compound

Procedure

The title compound, off-white solid, m.p. 166° C. and MS: m/e=355 (M+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and naphthalene-2-sulfonyl chloride.

Sources & evidence

ORD record
ord-3eb1322c54114e78b4accda1e3b374fe
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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