4-Chlorobenzenesulfonyl chloride → HCID 12132446, compound

HRID 1594756Notes

Reaction equation

HRID 1594756 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:9]2[CH2:10][CH2:11][CH2:12][C@@H:8]2[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)(=[O:22])=[O:21])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 7047818(R)-2-(4-Fluorophenyl)pyrrolidine

Product 1

HCID 12132446HCID 12132446, compound

Procedure

The title compound, white solid, m.p. 119° C. and MS: m/e=339 (M+) was prepared in accordance with the general method of example 1e from (R)-2-(4-fluoro-phenyl)-pyrrolidine and 4-chloro-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-651bce5d6be74e118b703e2d7ac8cc7f
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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