HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → (2S)-2-(4-Fluorophenyl)-1-(4-methylbenzene-1-sulfonyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | (S)-2-(4-Fluorophenyl)pyrrolidine | HCID 7022776 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (2S)-2-(4-Fluorophenyl)-1-(4-methylbenzene-1-sulfonyl)pyrrolidine | HCID 32681978 | — |
Reaction Steps
The title compound, white solid, m.p. 136° C., [a]D20=172° (c=0.1 in CHCl3) and MS: m/e=319 (M+) was prepared in accordance with the general method of example 1e from (S)-2-(4-fluoro-phenyl)-pyrrolidine and toluene-4-sulfonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06284785B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-d422d4e688b04971b1274271dbad4ebe |
| Source note | uspto-grants-2001_09 |