2-(4-Fluorophenyl)pyrrolidine → HCID 21706778, compound

HRID 1594764Notes

Reaction equation

HRID 1594764 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[OH:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2[S:21]([C:18]2[CH:17]=[CH:16][C:15]([CH2:14][OH:13])=[CH:20][CH:19]=2)(=[O:23])=[O:22])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 38655602-(4-Fluorophenyl)pyrrolidineHCID 21706752190711-48-9

Product 1

HCID 21706778HCID 21706778, compound

Procedure

The title compound, white solid, m.p. 107° C., and MS: m/e=336.2 (M+H+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and 4-hydroxymethyl-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-5c52d59eb147475694cd1008579bbdfc
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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