HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 3-[4-[1-(3-Chlorophenyl)-4-piperazinyl]butyl]-4-thiazolidinone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2-Chlorophenyl)piperazine dihydrochloride | HCID 3018683 | — |
| Reactant | 3-(4-Bromobutyl)-4-thiazolidinone | HCID 10847505 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-[4-[1-(3-Chlorophenyl)-4-piperazinyl]butyl]-4-thiazolidinone hydrochloride | HCID 14856136 | — |
Reaction Steps
To a solution of 3-(4-bromobutyl)-4-thiazolidinone (3.0 g) and 1-(2-chlorophenyl)piperazine dihydrochloride (3.4 g) in 100 ml of anhydrous CH3CN were added K2CO3 (8.7 g) and NaI (200 mg). The mixture was heated at 80° with stirring under N2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06284775B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-7f2af51c087d40209338598515fab5b4 |
| Source note | uspto-grants-2001_09 |