HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1594802Generated: November 4, 2026
Sodium Iodide → 3-(4-(1-(6-Chlorobenzo[b]thiophen-3-yl)-4-piperazinyl)butyl)-2,5,5-trimethyl-4-thiazolidinone hydrochloride
https://huagongshe.com/reaction/1594802
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(4-Bromobutyl)-2,5,5-trimethyl-4-thiazolidinone | HCID 10779094 | — |
| Reactant | 1-(6-Chlorobenzo[b]thien-3-yl)-piperazine | HCID 15541460 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(4-(1-(6-Chlorobenzo[b]thiophen-3-yl)-4-piperazinyl)butyl)-2,5,5-trimethyl-4-thiazolidinone hydrochloride | HCID 21706588 | 43% |
Reaction Steps
A mixture of 3-(4-bromobutyl)-2,5,5-trimethyl-4-thiazolidinone (5.00 g), 6-chloro-3-piperazinylbenzo[b]thiophene (5.41 g), K2CO3 (8.63 g) and NaI (400 mg) in acetonitrile (200 ml) was heated at 90° C. for 16.5 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.25 g of powder, m.p. 199-202° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06284775B1 |
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| Source dataset | uspto-grants-2001_09 |
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| ORD ID | ord-4893b93b308c4549b0a0e011fe7d7449 |
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| Source note | uspto-grants-2001_09 |
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