Water → HCID 18616551, compound

Participants

Reaction Steps

To a solution of 1-(5-amino-2-phenoxy-phenyl)ethanone (0.5 g, 2.20 mmol ) in THF (15 ml) was added sodium borohydride(0.4 g, 10.5 mmol ) and AlCl3 (anhydrous) (0.803 g, 6.02 mmol ) under nitrogen. The resulting reaction mixture was heated under reflux for 4 hours. Th e mixture was then cooled and iced-water added. The resultant mixture was extracted with EtOAc and dried over Na2SO4. Removal of the solvent afforded a brownish residue which was chromatographed with 4:1 hexane/EtOAc to afford (15 mg, 10%) product 3-ethyl-4-phenoxy-phenylamine.

Provenance & Evidence