hexahydro-3-(3-methoxyphenyl)-1-methyl-2H-azepin-2-one → hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one

Participants

Reaction Steps

3-(3-Methoxy-phenyl)-1-methyl-azepan-2-one (as described in Step A above) (1.067 g, 4.58 mmol) was refluxed in 48% HBr (5 mL) for 1 h. The reaction was diluted with EtOAc, washed with H2O, brine, dried (MgSO4), and concentrated to give the title compound.

Provenance & Evidence