反应详情

A 1M solution of BBr3(1.48 mL, 1.48 mmol) in CH2Cl2 was added to 3-methoxymethyl-3-(3-methoxy-phenyl)-1-methyl-azepan-2-one (as described in Step A above) (0.391 g, 1.35 mmol) dissolved in anh. CH2Cl2 (5 mL) at −78° C. After 24 h of stirring at RT, the reaction was quenched with H2O, extracted with CH2Cl2 (3×), dried (MgSO4), concentrated and purified using SiO2 chromatography (1-1.5% MeOH/CH2Cl2with HOAc) to give the title compound.

1. customthe reaction was quenched with H2O
2. extractionextracted with CH2Cl2 (3×)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated
5. custompurified