HCID 21706294, compound → HCID 21706213, compound

Participants

Reaction Steps

To a solution of 2-[(4-bromo-3-fluoro-phenyl)-chloro-methyl]-pyridine (as described in Step C above) (0.29 g, 0.965 mmol) in HOAc (10 mL) was added zinc powder (0.315 g, 4.82 mmol) and the mixture was refluxed for 1 hr. The HOAc was removed in vacuo and the residue was partitioned with EtOAc and saturated NaHCO3. The EtOAc was washed with H2O, brine, dried with MgSO4, and evaporated in vacuo to obtain the title compound which was used without further purification.

Provenance & Evidence