{2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-tert-butyl Urea → {2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-urea

HRID 1594895Notes

Reaction equation

HRID 1594895 reaction equation
[C:1]([C:3]1[CH:25]=[CH:24][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][N:15](C(C)(C)C)[C:16]([NH2:18])=[O:17])=[CH:11][N:10]=[C:9]2[CH3:23])=[CH:5][C:4]=1[F:26])#[N:2]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[C:1]([C:3]1[CH:25]=[CH:24][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][NH:15][C:16]([NH2:18])=[O:17])=[CH:11][N:10]=[C:9]2[CH3:23])=[CH:5][C:4]=1[F:26])#[N:2]

Participants

3

Reactant 1

HCID 21706166{2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-tert-butyl Urea

Product 1

HCID 21706187{2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-urea

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

{2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-tert-butyl urea (as described above in Step A) (0.41 g) was dissolved in TFA/CH2Cl2 3:1 (5.0 mL) and stirred at ambient temperature for 72 hr. The solvents were removed in vacuo to obtain the title compound.

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-03783438f5e64051b19f30ce6e5706ce
Source dataset
uspto-grants-2001_09
Patent number
US06284755B1

Reaction notes

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