2-Fluoro-4-formylbenzonitrile → HCID 178509633, compound

HRID 1594900Notes

Reaction equation

HRID 1594900 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([CH:10]=O)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:12][CH2:13][CH2:14][C:15]1[N:19]=[CH:18][NH:17][CH:16]=1>>[F:1][C:2]1[CH:9]=[C:8]([CH:10]2[C:16]3[NH:17][CH:18]=[N:19][C:15]=3[CH2:14][CH2:13][NH:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 112173392-Fluoro-4-formylbenzonitrileHCID 178419017HCID 178419017, compound

Product 1

HCID 178509633HCID 178509633, compound

Procedure

2-Fluoro-4-formyl-benzonitrile (as described in Example 29, Step A) (0.268 g, 1.79 mmol) and histamine (0.200 g, 1.79 mmol) were heated neat at 120° C. for 1.5 h. The molten liquid was cooled to give the title compound.

Workup

  1. temperatureThe molten liquid was cooled

Sources & evidence

ORD record
ord-3d1c99e620694bab8e070965c2522a5a
Source dataset
uspto-grants-2001_09
Patent number
US06284755B1

Reaction notes

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