反应详情

To a solution of 3-ethyl-3-(3-hydroxy-phenyl)-azepan-2-one (Example 8, Step B) (1.28 g, 0.0055 mol) in DMF (50 mL) was added Cs2CO3 (1.79 g, 0.055 mmol) and benzyl bromide (0.653 mL, 0.0055 mmol) at ambient temperature. After 1.5 h the reaction was concentrated to remove most of the DMF and the residue was partitioned between EtOAc and H2O. The aqueous layer was washed with EtOAc, the organics combined, washed with brine, and dried (MgSO4). Filtration and concentration to dryness gave the title compound.

1. concentrationAfter 1.5 h the reaction was concentrated
2. customto remove most of the DMF
3. customthe residue was partitioned between EtOAc and H2O
4. washThe aqueous layer was washed with EtOAc
5. washwashed with brine
6. dry with materialdried (MgSO4)
7. filtrationFiltration and concentration to dryness