反应详情

BBr3 (1M in CH2Cl2) (1 mL, 1 mmol) was added dropwise to a solution of 7-(1-methyl-3-methoxyphenyl)-azepan-2-one, as described in Step D above, (0.06 g, 0.26 mmol) in CHCl3 (1 mL) at 0° C. with stirring. The ice bath was removed and stirring was continued for 1 h. The reaction mixture was partitioned between EtOAc (100 mL)—H2O (100 mL), the organic layer separated, washed with H2O, dried (MgSO4), filtered and concentrated to give the title compound after SiO2 chromatography (CHCl3:MeOH, 10:1).

1. customat 0° C.
2. customThe ice bath was removed
3. stirringstirring
4. customThe reaction mixture was partitioned between EtOAc (100 mL)—H2O (100 mL)
5. customthe organic layer separated
6. washwashed with H2O
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. concentrationconcentrated