HCID 21706235, compound → HCID 21706239, compound

HRID 1594925Notes

Reaction equation

HRID 1594925 reaction equation
[CH2:1]([C:4]1([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=2)[O:9][CH2:8][CH2:7][N:6]([CH3:10])[C:5]1=[O:11])[CH:2]=[CH2:3]>CO>[CH3:19][O:18][C:14]1[CH:13]=[C:12]([C:4]2([CH2:1][CH2:2][CH3:3])[O:9][CH2:8][CH2:7][N:6]([CH3:10])[C:5]2=[O:11])[CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 1

HCID 21706235HCID 21706235, compound

Product 1

HCID 21706239HCID 21706239, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Allyl-2-(-3-methoxy-phenyl)-4-methyl-morpholine-3-one, as described above in Step C, (0.400 g, 1.53 mmol) was dissolved in MeOH (20 mL), the solution purged with Ar, treated with 10% Pd/C (0.060 g), and hydrogenated under a H2 balloon. After 2 h the reaction mixture was filtered through a celite pad and concentrated to dryness to give the title compound.

Workup

  1. customthe solution purged with Ar
  2. additiontreated with 10% Pd/C (0.060 g)
  3. filtrationAfter 2 h the reaction mixture was filtered through a celite pad
  4. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-d1d3b5cce53d45f086f6e6e65979d9f2
Source dataset
uspto-grants-2001_09
Patent number
US06284755B1

Reaction notes

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