Morpholine → HCID 890650, compound

HRID 1594927Notes

Reaction equation

HRID 1594927 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9](Cl)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>CC(C)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 27375043-Methoxybenzenesulfonyl chloride

Product 1

HCID 890650HCID 890650, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

3-Methoxybenzenesulfonyl chloride (0.20 g, 0.968 mmol) in acetone (2 mL) at 0° C. was treated with excess morpholine (0.253 mL, 2.9 mmol) with stirring. After 0.5 hr the reaction mixture was partitioned between CH2Cl2 (1 mL) and 1N HCl, the organic layer separated, washed with brine, dried (Na2SO4), filtered and concentrated to dryness to give the title compound.

Workup

  1. customAfter 0.5 hr the reaction mixture was partitioned between CH2Cl2 (1 mL) and 1N HCl
  2. customthe organic layer separated
  3. washwashed with brine
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-ab8a1b73c0184e5da0e648aa52461bd1
Source dataset
uspto-grants-2001_09
Patent number
US06284755B1

Reaction notes

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