Aluminum(III) Chloride → HCID 21707192, compound

HRID 1594934Notes

Reaction equation

HRID 1594934 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([O:13]C)[CH:12]=1)[C:9](=[O:15])[CH2:8][CH2:7][CH2:6]2.[Al+3].[Cl-].[Cl-].[Cl-]>C(Cl)Cl>[OH:13][C:11]1[CH:12]=[C:3]([O:2][CH3:1])[CH:4]=[C:5]2[C:10]=1[C:9](=[O:15])[CH2:8][CH2:7][CH2:6]2

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 114470756,8-dimethoxy-3,4-dihydro-2H-naphthalen-1-one

Product 1

HCID 21707192HCID 21707192, compoundYield 98.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 6,8-dimethoxy-3,4-dihydro-2H-naphthalen-1-one (15 g, 72.8 mmole), prepared according to the procedure of J. Chem. Soc., London 2782 (1955), which is incorporated herein by reference, in methylene chloride (150 mL) at 0° C. was treated portionwise with AlCl3 (14.3 g, 107 mmole), stirred for 20 h at room temperature, poured onto ice with stirring and extracted with methylene chloride when the ice melted. The extracts were washed with water and brine, dried (MgSO4) and concentrated to provide 13.8 g of the title compound.

Workup

  1. additionpoured onto ice
  2. stirringwith stirring
  3. extractionextracted with methylene chloride when the ice
  4. washThe extracts were washed with water and brine
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-d9c86aea544c469ebe9315f7aab64bf7
Source dataset
uspto-grants-2001_09
Patent number
US06284796B1

Reaction notes

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