Leucine, N-carboxy-, N-benzyl ester, L- → (2S)-2-(benzyloxycarbonyl)amino-N-(4-carboethoxythiazol-2-yl)methyl-4-methylpentanamide

Participants

Role	Name	HCID	Charge
Reactant	Leucine, N-carboxy-, N-benzyl ester, L-	HCID 74840	—
Reactant	N-((Phenylmethoxy)carbonyl)-L-leucyl-L-leucine	HCID 7299379	—
Reactant	(1S)1-(tert-butoxycarbonyl)amino-1-(4carboethoxythiazol-2-yl)-3-methylbutane	HCID 14680168	—
Product	(2S)-2-(benzyloxycarbonyl)amino-N-(4-carboethoxythiazol-2-yl)methyl-4-methylpentanamide	HCID 18396119	—

Reaction Steps

Following the procedure of Example 13, except substituting 1-(tert-butoxycarbonyl)amino-1-(4-carboethoxythiazol-2-yl)methane for (1S)-1-(tert-butoxycarbonyl)amino-1-(4-carboethoxythiazol-2-yl)-3-methylbutane, and N-Cbz-L-leucine for N-Cbz-L-leucinyl-L-leucine, the title compound was prepared (0.120 g, 32%). MS (MH+): 434.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06284777B1
Source dataset	uspto-grants-2001_09
ORD ID	ord-64d9fb96ba7b452a811b8983dec77c20
Source note	uspto-grants-2001_09