(3S)-3-acetyloxy-4-bromobutanoic acid → (s)-3,4-Epoxybutyric acid calcium salt

Participants

Reaction Steps

A solution of distilled water (10 ml), (S)-3-acetoxy-4-bromobutyric acid (0.9 g, 0.004 mol) and calcium hydroxide (0.45 g, 0.006 mol) was charged to 100 ml flask equipped with a thermometer, pH meter and agitator, and stirred at 0˜5° C. for 2 hours to give (S)-3,4-epoxybutyric acid calcium salt. It was confirmed by a NMR analysis that more than 99% (S)-3,4-epoxybutyric acid calcium salt was converted.

Provenance & Evidence