Methanol → (s)-3,4-Epoxybutyric acid tetrabutylammonium salt

Participants

Reaction Steps

A solution of distilled water (10 ml), (S)-3-acetoxy-4-bromobutyric acid (0.9 g, 0.004 mol) and 1.0M methanol (12 ml, 0.012 mol) in tetrabutylammonium hydroxide was charged to 100 ml flask equipped with a thermometer, pH meter and agitator, and stirred at 0˜5° C. for 2 hours to give (S)-3,4-epoxybutyric acid tetrabutylammonium salt. It was confirmed by a NMR analysis that more than 99% (S)-3,4-epoxybutyric acid tetrabutylammonium salt was converted.

Provenance & Evidence