Tert-Butylamine → (s)-3,4-Epoxybutyric acid t-butylamine salt

Participants

Reaction Steps

A solution of distilled water (10 ml), (S)-3-acetoxy-4-bromobutyric acid (0.9 g, 0.004 mol) and t-butylamine (0.08 g, 0.012 mol) was charged to 100 ml flask equipped with a thermometer, pH meter and agitator, and stirred at 0˜5° C. for 2 hours to give (S)-3,4-epoxybutyric acid t-butylamine salt. It was confirmed by a NMR analysis that more than 99% (S)-3,4-epoxybutyric acid t-butylamine salt was converted.

Provenance & Evidence