Methanesulfonic Acid → HCID 11322135, compound

Participants

Reaction Steps

1,4-Dicyanobenzene (2.0 g; 15.6 mmol) and palladium on activated carbon (1.0 mol % Pd/1,4-dicyanobenzene) were suspended in iso-propanol (30 mL) at 50° C. Hydrogen was continuously added at a pressure of 6 atm. When the desired conversion was obtained (2.5 h), the hydrogen was replaced by nitrogen and the solid material (Pd/C and unreacted 1,4-dicyanobenzene) was filtered off. Methanesulphonic acid (1.5 g; 15.6 mmol) was added to the clear solution. The crystals which formed were centrifuged, washed with a small amount iso-propanol and dried to yield 2.77 g (79%) of 4-cyanobenzylammonium methanesulphonate with a HPLC purity of 91.2 ae %.

Provenance & Evidence