HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → HCID 21706309, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | HCID 21706358 | HCID 21706358 | — |
| Reactant | TFA triethylsilane | HCID 131722655 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Oxalate | HCID 71081 | — |
| Product | HCID 21706309 | HCID 21706309 | 27% |
Reaction Steps
The title compound was prepared in 27% yield in three steps from LAH reduction of methyl 4-[4-[5-methoxy-3-[3-methoxy-4-(1-pyrrolidinylmethyl)benzoyl]benzo[b]thiophen-2-yl]phenoxy]butyrate (Part C of Example 38) in THF at 0-10° C. for 1 h, followed by dehydroxylation with Et3SiH/TFA in CH2Cl2 and oxalate formation as previously described.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06284756B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-b3418baeee6548dbbee8794f8405054a |
| Source note | uspto-grants-2001_09 |