Diethyl acetamide 2-(4-octanoyl phenyl)ethyl malonate → Diethyl acetamide 2(4-octyl phenyl)ethyl malonate

Participants

Reaction Steps

Diethyl acetamide-2-(4-octanoyl phenyl)ethyl malonate prepared in the step J (923 g) was stirred in ethanol (10 L) under atmosphere of hydrogen in the presence of 5% palladium carbon (138 g) overnight. The catalyst was removed by filtration, and the filtrate was concentrated. The residue was recrystallized from hexane to obtain diethyl acetamide-2(4-octyl phenyl)ethyl malonate (670 g) in the form of colorless crystal.

Provenance & Evidence