3,4-Dimethoxyaniline → HCID 12016884, compound

HRID 1595085Notes

Reaction equation

HRID 1595085 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[NH2:6].[F:12][C:13]1[CH:14]=[C:15]([S:27](Cl)(=[O:29])=[O:28])[CH:16]=[C:17]([N+:24]([O-:26])=[O:25])[C:18]=1[O:19][C:20]([F:23])([F:22])[F:21]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:6][S:27]([C:15]2[CH:16]=[C:17]([N+:24]([O-:26])=[O:25])[C:18]([O:19][C:20]([F:21])([F:22])[F:23])=[C:13]([F:12])[CH:14]=2)(=[O:29])=[O:28])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 227703,4-DimethoxyanilineHCID 12016883HCID 12016883, compound

Product 1

HCID 12016884HCID 12016884, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3,4-Dimethoxyaniline (1.53 g, 10 mmol) is added to a solution of 3-fluoro-5-nitro-4-trifluoromethoxyphenylsulfonyl chloride (2.87 g, 12 mmol) in MeOH (20 ml) at ambient temperature. After stirring at room temperature for 15 min, the reaction mixture is concentrated under reduced pressure and the residue is taken up in ethyl acetate and filtered through a pad of silica gel. Concentration of the filtrate, followed by chromatography, provides the title compound.

Workup

  1. concentrationthe reaction mixture is concentrated under reduced pressure
  2. filtrationfiltered through a pad of silica gel

Sources & evidence

ORD record
ord-0bb390432bb14170be51eb961967ae3b
Source dataset
uspto-grants-2001_09
Patent number
US06284923B1

Reaction notes

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