Potassium bis(trimethylsilyl)amide → HCID 23684418, compound

HRID 1595106Notes

Reaction equation

HRID 1595106 reaction equation
[CH3:1][C:2]1[CH2:3][C:4]2[C:9]([CH:10]=1)=[C:8](C1C3C(=CC=CC=3)C=CC=1)[CH:7]=[CH:6][CH:5]=2.C[Si]([N-][Si](C)(C)C)(C)C.[K+:30]>C1(C)C=CC=CC=1>[CH3:10][C:2]1[CH:1]=[C:10]([C:2]2[CH-:3][C:4]3[C:9]([CH:1]=2)=[CH:8][CH:7]=[CH:6][CH:5]=3)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[K+:30]

Participants

4

Reactant 2

HCID 3251421Potassium bis(trimethylsilyl)amideHCID 177791321-(2-Methyl-1H-inden-4-yl)naphthalene

Product 1

HCID 23684418HCID 23684418, compoundYield 228.5%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-Methyl-4-naphthylindene (1.00 g, 3.27 mmole) was dissolved in 20 ml of toluene, potassium bis(trimethylsilyl)amide (1.05 equivalent, 3.43 mmole, 0.684 g) was added and the reaction mixture was stirred at room temperature for 24 hours, during which a yellow solid precipitated. Hexane was added (20 ml) and the mixture was stirred for 2 h. The solid product was isolated by vacuum filtration through a medium porosity frit. The solid was pumped dry giving 1.10 g, 98 percent of the desired product.

Workup

  1. customprecipitated
  2. additionHexane was added (20 ml)
  3. stirringthe mixture was stirred for 2 h
  4. customThe solid product was isolated by vacuum filtration through a medium porosity frit
  5. customThe solid was pumped dry

Sources & evidence

ORD record
ord-487154d8dff5413a8ac1f89d001577a3
Source dataset
uspto-grants-2001_09
Patent number
US06284905B1

Reaction notes

Loading…