HCID 10736665, compound → HCID 10899439, compound

Participants

Reaction Steps

(3R, 5S, 7R)-4-Benzoyl-7-benzyloxy-3-methyl-1-oxa-4-azaspiro[4.4]nonane (250 mg, 0.7 mmol) were dissolved in 5 ml of CH3CN. IR 120[H+] (washed 2× with ethanol and 1× with H2O) was added to a pH of 5-6, The mixture was stirred at room temperature until starting material was no longer detectable. The reaction mixture was filtered and the filtrate was concentrated on a rotary evaporator. After column chromatography, (R)-3-benzyloxycyclopentanone (81 mg, 0.4 mmol) was obtained.

Provenance & Evidence