反应详情

10.8 g of 4-(3-chloro-4-methoxybenzyl)amino-6-cyano-1-(4-hydroxypiperidino)phthalazine was suspended in a mixture of ethanol (60 ml) with water (30 ml) and 30 ml of a 1 N aqueous solution of hydrochloric acid was added thereto. After dissolving by heating once, the mixture was cooled by allowing to stand at room temperature. The resulting crystals were collected by filtration and hot air-dried at 80° C. overnight to give 9.37 g of the title compound as yellow crystals. M.p. 217-227° C. (decomp.), Mass 424 (MH+),

1. additionwas added
2. dissolutionAfter dissolving
3. temperatureby heating once
4. temperaturethe mixture was cooled
5. customto stand at room temperature
6. filtrationThe resulting crystals were collected by filtration
7. customhot air-dried at 80° C. overnight