HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)propanoic acid → 3alpha-N-(N-tert-butyloxycarbonyl-O-benzyl-D-seryl)aminocholestane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)propanoic acid | HCID 2733693 | — |
| Reactant | 3Alpha-aminocholestane | HCID 10872780 | — |
| Product | 3alpha-N-(N-tert-butyloxycarbonyl-O-benzyl-D-seryl)aminocholestane | HCID 54282505 | 83% |
Reaction Steps
By using N-tert-butyloxycarbonyl-O-benzyl-D-serine (600 mg, 2.03 mmol) and 3α-aminocholestane (866 mg, 2.23 mmol), the title compound was obtained in the same manner as in Synthetic Example BB1 (1.13 g, yield; 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06288041B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-8a1cbf2faeeb467ba2cd879e64043617 |
| Source note | uspto-grants-2001_09 |