Water → HCID 73827708, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-fluorophenyl-2-(4-pyridyl)acetophenone (8.08 g, 37.6 mmol) [See PCT/US93/00674, Adams et al., WO93/14081] in EtOH (80 mL) was added hydroxylamine hydrochloride (4.12 g, 59.7 mmol) and pyridine (4.8 mL, 59.7 mmol). The mixture was stirred at 60 ° C. for 1 h, then poured into H2O and stirred an additional 1 min. The resulting precipitate was filtered and washed with H2O. The precipitate was recrystallized from EtOH/H2O to give the title compound as a white solid (6.29 g): mp 135-136° C.

Provenance & Evidence