HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1595207Generated: November 2, 2026
HCID 54348134, compound → HCID 72609440, compound
https://huagongshe.com/reaction/1595207
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 54348134 | HCID 54348134 | — |
| Reactant | HCID 54395891 | HCID 54395891 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 72609440 | HCID 72609440 | 31.2% |
Reaction Steps
0.25 g of Pd(TPP)2Cl2 and also 0.1 g of copper(I) iodide are added, under an argon atmosphere, to a solution of 10.0 g of 1-(3-trifluoromethylphenyl)ethanone O-prop-2-ynyl-oxime in 150 ml of triethylamine and the mixture is heated to 70° C. 8.9 g of 2-bromo-3-methoxyacrylic acid methyl ester in 30 ml of tetrahydrofuran are then added and the mixture is stirred at 70° C. for 14 h and then filtered. The filtrate is concentrated by evaporation and chromatographed on silica gel (hexane/diethyl ether 2:1) to yield 4.6 g of the product having a melting point of 57-58° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06288071B1 |
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| Source dataset | uspto-grants-2001_09 |
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| ORD ID | ord-60954ac2204240f0b3d0ce0d1703c320 |
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| Source note | uspto-grants-2001_09 |
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