Phloroglucinol → HCID 10540475, compound

Participants

Reaction Steps

3.5 g of 1,3,5-trihydroxybenzene and 62.5 mg of para-toluenesulphonic acid are added to a solution of 5 g of 3-amino-2-naphthalenecarboxylic acid in 50 ml of heptan-1-ol. The mixture is maintained at reflux using a Dean-Stark apparatus for 48 hours, with stirring, and the reaction mixture is then concentrated in vacuo. The residue is chromatographed on silica gel (eluant: cyclohexane/acetone: 90/10). The isolated product is crystallised from a cyclohexane/acetone mixture, yielding 5.2 g of the expected product.

Provenance & Evidence