Acetic Anhydride → HCID 10769038, compound

HRID 1595212Notes

Reaction equation

HRID 1595212 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[OH:8][C@@H:9]1[C:14]2=[C:15]3[C:24](=[C:25]([O:27][CH3:28])[CH:26]=[C:13]2[O:12][C:11]([CH3:36])([CH3:35])[C@@H:10]1[O:37][C:38](=[O:45])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[C:23](=[O:29])[C:22]1[CH:21]=[C:20]2[CH:30]=[CH:31][CH:32]=[CH:33][C:19]2=[CH:18][C:17]=1[N:16]3[CH3:34]>N1C=CC=CC=1>[C:1]([O:8][C@@H:9]1[C:14]2=[C:15]3[C:24](=[C:25]([O:27][CH3:28])[CH:26]=[C:13]2[O:12][C:11]([CH3:36])([CH3:35])[C@@H:10]1[O:37][C:38](=[O:45])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[C:23](=[O:29])[C:22]1[CH:21]=[C:20]2[CH:30]=[CH:31][CH:32]=[CH:33][C:19]2=[CH:18][C:17]=1[N:16]3[CH3:34])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 10697005HCID 10697005, compound

Product 1

HCID 10769038HCID 10769038, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2.5 ml of acetic anhydride are added to a solution of 0.1 g of the compound of Example 20 in 2.5 ml of pyridine. After reacting for 12 hours at room temperature, the reaction mixture is concentrated under reduced pressure. Chromatography on silica gel (eluant: dichloromethane) allows the expected product to be isolated.

Workup

  1. concentrationthe reaction mixture is concentrated under reduced pressure
  2. customto be isolated

Sources & evidence

ORD record
ord-b2c020d5b0484a8281e1059e6bb0a4a1
Source dataset
uspto-grants-2001_09
Patent number
US06288073B1

Reaction notes

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