Sodium Cyanide → 6-Amino-2-methylpyridine-3-carbonitrile

Participants

Reaction Conditions

Reaction Steps

Copper(I) cyanide (12 mmol) is added to 10 mmol of 6-amino-3-bromo-2-methylpyridine dissolved in dimethylformamide. The mixture is heated at reflux for 10 hours and then cooled to 80° C. and poured into a solution of sodium cyanide (40 mmol) in water. After stirring for one hour at ambient temperature, the mixture is extracted with ethyl acetate. The organic phase is washed and then dried and evaporated to yield the expected product in the form of an ochre solid.

Provenance & Evidence